tert-butoxycarbonyl anhydride

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CAS Number: 24424-99-5
Price: 200
Quantity: 1KG
Purity: 99

CAS No. 24424-99-5
Molecular Formula C10H18O5
Molecular Weight 218.24700
PSA 61.83000
LogP 2.87320
Appearance & Physical State White to off-white microcrystalline powder
Density 0.95 g/mL at 25 °C(lit.)
Boiling Point 65-67 °C
Melting Point 23 °C(lit.)
Flash Point 99 °F
Refractive Index n20/D 1.409(lit.)
Storage Condition 2-8°C

Di-tert-butyl dicarbonate is a reagent widely used in organic synthesis. This carbonate ester reacts with amines to give N-tert-butoxycarbonyl or so-called Boc derivatives. These derivatives do not behave as amines, which allows certain subsequent transformations to occur that would have otherwise affected the amine functional group. The Boc can later be removed from the amine using acids. Thus, Boc serves as a protective group, for instance in solid phase peptide synthesis. It is unreactive to most bases and nucleophiles, allowing for an orthogonal Fluorenylmethyloxycarbonyl chloride (FMOC-Cl) protection.
Basic Info
Chemical Name tert-butoxycarbonyl anhydride
Pyrocarbonic Acid Di-tert-butyl Ester;
Di-tert-butyl Pyrocarbonate;

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CAS Number: 24424-99-5

Basic Information of 24424-99-5

IUPAC Name: tert-butyl (2-methylpropan-2-yl)oxycarbonyl carbonate
Formula: C10H18O5

Chemical Properties of tert-butoxycarbonyl anhydride

Weight: 218.24692
Density: 0.949
Melting Point: 22-24°C
Boiling Point: 56-57°C (0.5 torr)
Flash Point: 37°C
Vapour: 0.7 mmHg at 25°C
Refractive Index: 1.4075-1.4095
Solubility: Insoluble