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Taizhou Crene Biotechnology Co., Ltd.

Address:Economic Developed Zone of Taizhou Zhejiang China., Taizhou

Zhejiang, 318000

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BIBW2992 Afatinib Image

BIBW2992 Afatinib

CAS Number: 439081-18-2
Afatinib is an irreversible, dual EGFR/HER2 inhibitor, shows potent activity against wild-type and mutant forms of EGFR and HER2, with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Afatinib dimaleate is an irreversible, dual EGFR/HER2 inhibitor, shows potent activity against wild-type and mutant forms of EGFR and HER2, with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2, respectively.
Cetuximab Image

Cetuximab

CAS Number: 205923-56-4
Cetuximab is an epidermal growth factor receptor (EGFR) inhibitor used for the treatment of metastatic colorectal cancer, metastatic non-small cell lung cancer and head and neck cancer. Cetuximab is a chimeric (mouse/human) monoclonal antibody given by intravenous infusion that is distributed under the trade name Erbitux in the U.S. and Canada by the drug company Bristol-Myers Squibb and outside the U.S. and Canada by the drug company Merck KGaA. In Japan, Merck KGaA, Bristol-Myers Squibb and Eli Lilly have a co-distribution.
Anidulafungin (LY303366) Image

Anidulafungin (LY303366)

CAS Number: 166663-25-8
Anidulafungin (LY303366) is a new semisynthetic echinocandin with antifungal potency. Anidulafungin (LY-303366) has MICs of ≤0.32 μg/mL for all Candida albicans (n=99), Candida glabrata (n=18), and Candida tropicalis (n=10) isolates tested. Anidulafungin is also active against Aspergillus species (minimum effective concentration at which 90% of the isolates are inhibited, 0.02 μg/mL) (n=20), is less active against Candida parapsilosis (MIC at which 90% of the isolates are inhibited [MIC90], 5.12 μg/mL) (n=10), and is inactive against C. neoformans (MIC90 >10.24 μg/mL) (n=15) and B. dermatitidis (MIC90, 16 μg/mL) (n=29).The MICs of Fluconazole for three strains of C. tropicalis, seven strains of C. glabrata, and two strains of Candida krusei are ≥16 μg/mL. The MICs of Anidulafungin for 11 of these 12 strains range from 0.08 to 0.32 mg/mL. The twelfth strain is a C. krusei strain (Fluconazole MIC, 32 μg/mL) for which the Anidulafungin MIC is 1.28 mg/mL. The MIC at which 90% of the isolates are inhibited (MIC90) for these 12 strains is 0.32 μg/mL. The Anidulafungin MIC90 for the remaining 18 C. glabrata isolates and C. tropicalis isolates for which the Fluconazole MICs are ≥ 8 μg/mL is also 0.32 mg/mL. Anidulafungin appeares equally active against Candida species for which the fluconazole MICs are ≥16 mg/mL and against those for which the fluconazole MICs are ≥ 8 μg/mL. Anidulafungin has significantly less activity against C. neoformans and B. dermatitidis than against C. albicans, C. glabrata, and C. tropicalis. Ketoconazole and amphotericin B are the most active antifungal agents tested for both C. neoformans and B. dermatitidis. Anidulafungin demonstrated potent in vitro activity against Aspergillus species with a MEC90 of 0.02 μg/mL. MICs of Anidulafungin for the control strain yeast isolates are 0.02 μg/mL for C. albicans ATCC 90028, 0.16 mg/mL for C. glabrata ATCC 90030, and >10.24 μg/mL for C. neoformans ATCC 90112[1]. Strains selected with CD101 that have a 2-fold or greater CD101 MIC increase also have at least a 2-fold MIC increase for Anidulafungin (ANF) and/or Caspofungin (CSF)[2].
Echinocandin B Image

Echinocandin B

CAS Number: 79411-15-7
Echinocandin B
Properties: Density: 1.6 Boiling Point: 1330.8ºC at 760 mmHg Flash Point: 758.6ºC Refractive Index: 1.689
ECBN HCL Image

ECBN HCL

CAS Number: 1029890-89-8
ECBN HCL
Synonyms: 1-[(4R,5R)-4,5-Dihydroxy-L-ornithine]echinocandin B hydrochloride (1:1);Echinocandin B nucleus hydrochloride;ECBN;ECBN HCL;1-[(4R,5R)-4,5-Dihydroxy-L-ornithine]echinocandin B hydrochloride;1-[(4R,5R)-4,5-Dihydroxy-L-ornithine]echinocandin B hydrochloride (1;Anidulafungin Nucleus Smiles O=C1N2[C@@](C(N[C@@H]([C@@H](C[C@@H](C(NC([C@H](O)C)C(N3[C@](C[C@@H](O)C3)([H])C(NC([C@H](O)[C@H](C4=CC=C(O)C=C4)O)C(N[C@@]1([H])[C@H](O)C)=O)=O)=O)=O)N)O)O)=O)([H])[C@@H](O)[C@@H](C)C2.Cl InChI InChI=1S/C34H51N7O15.ClH/c1-12-10-41-24(25(12)47)32(54)39-30(52)20(46)9-18(35)28(50)36-21(13(2)42)33(55)40-11-17(45)8-19(40)29(51)38-23(31(53)37-22(14(3)43)34(41)56)27(49)26(48)15-4-6-16(44)7-5-15;/h4-7,12-14,17-27,30,42-49,52H,8-11,35H2,1-3H3,(H,36,50)(H,37,53)(H,38,51)(H,39,54);1H/t12-,13+,14+,17+,18-,19-,20+,21?,22-,23?,24-,25-,26-,27-,30+;/m0./s1
Micafungin sodium Image

Micafungin sodium

CAS Number: 208538-73-2
Micafungin sodium is an inhibitor of 1, 3-beta-D-glucan synthesis, and used as an antifungal drug. Micafungin (10 mg/mL) phenotypicly decreases the formation of biofilm in most of the isolates. For all the genes tested, the levels of mRNA transcription are also decreased significantly in micafungin-treated samples cf. their untreated counterparts[1]. The combination of micafungin and KB425796-C is fungicidal and markedly reduces the number of CFU, in contrast to the fungistatic effects (no reduction in CFU) observed at all examined time points when each drug is used alone[2]. Micafungin (1 mg/kg) significantly prolongs survival compared with mice administered saline. Animals given a combination of micafungin (0.1 mg/kg) and KB425796-C (32 mg/kg) show a trend towards prolonged survival in comparison with those treated with micafungin (0.1 mg/kg) alone. In the livers of micafungin-treated mice, the number of CFUs decreases, although the clearance effect is less than that found in the kidneys. Combination treatment with micafungin and KB425796-C results in a significant decrease in the number of CFUs compared with the treatment with micafungin alone at all examined doses. The clearance effect associated with KB425796-C in combination with micafungin is greater than that observed in AMPH-treated animals[2].
Micafungin FR-179642 impurity acid Image

Micafungin FR-179642 impurity acid

CAS Number: 168110-44-9
FR 179642 is an impurity of Micafungin, a lipopeptide compound that acts as an antifungal agent with activity against Aspergillus and Candida species.
Caspofungin acetate Image

Caspofungin acetate

CAS Number: 179463-17-3
Caspofungin acetate is an lipopeptide antifungal β-1,3-glucan synthase inhibitor. Mice injected with caspofungin at vitreal concentrations from 0.41 to 4.1 μM do not have significant alterations in their ERG waveforms, and their retinas have no detectable morphologic changes or loss of cells. At the vitreal concentration of 41 μM, caspofungin reduces the amplitudes of the a-waves, b-waves, and scotopic threshold responses of the ERG and also produces a decrease in the number of cells in the ganglion cell layer[1]. Caspofungin (8 mg/kg) or amphotericin B at 1 mg/kg given i.p. once daily for 7 days beginning at 30 h after infection resulted in 100% survival through day 28 relative to vehicle control treatment, which results in 100% mortality by day 11 after infectious challenge. Caspofungin reduces recovery of viable Candida from kidney and brain tissues compared to vehicle control treatment on day 5, when control burden peaked. Caspofungin-treated mice dosed with 2 mg/kg or greater have significantly lower brain burden than amphotericin-B-treated mice at day 5. Amphotericin B and caspofungin treatment reduce kidney fungal burden by 1.7 log CFU/g and 2.46 to 3.64 log CFU/g, respectively.
Pneumocandin B0 Image

Pneumocandin B0

CAS Number: 135575-42-7
Pneumocandin B0(L-688786), a key intermediate in the synthesis of the antifungal agent, Cancidas, has led to the identification of several materials with potential for improved performance.
Afatinib dimaleate Image

Afatinib dimaleate

CAS Number: 850140-73-7
Afatinib dimaleate is an orally bioavailable dual receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. EGFR/HER2 tyrosine kinase inhibitor BIBW 2992 irreversibly binds to and inhibits human epidermal growth factor receptors 1 and 2 (EGFR-1; HER2), which may result in the inhibition of tumor growth and angiogenesis. EGFR/HER2 are RTKs that belong to the EGFR superfamily; both play major roles in tumor cell proliferation and tumor vascularization and are overexpressed in many cancer cell types. Afatinib is approved in much of the world (including the United States, Canada, the United Kingdom and Australia) for the treatment of metastatic non-small cell lung carcinoma (NSCLC), developed by Boehringer Ingelheim. It acts as an angiokinase inhibitor.
Idelalisib CAL-101 Image

Idelalisib CAL-101

CAS Number: 870281-82-6
CAL-101 is a highly selective and potent p110δ inhibitor with IC50 of 2.5 nM, is 40- to 300-fold more selective for p110δ relative to other PI3K class I enzymes (p110α, p110β, and p110γ; IC50 are 820, 565, and 89nM, respectively).
4-(3-Chloro-4-fluorophenylamino)-7-fluoro-6-nitroquninazoline Image

4-(3-Chloro-4-fluorophenylamino)-7-fluoro-6-nitroquninazoline

CAS Number: 162012-67-1
Price: 1
4-(3-Chloro-4-fluorophenylamino)-7-fluoro-6-nitroquninazoline is an intermediate in the synthesis of Afatinib, an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.
Afatinib Intermediates 314771-88-5 Image

Afatinib Intermediates 314771-88-5

CAS Number: 314771-88-5
Price: 1
(S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine is a used in the synthetic preparation of 4-anilinoquinazolines with C-6 urea-linked side chains as inhibitors of epidermal growth factor receptor. It is also used in the preparation of (2Z)-Afatinib which is used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.
Afatinib IMpurity B Image

Afatinib IMpurity B

CAS Number: 314771-76-1
Price: 1
Afatinib-des(4-dimethylamino-2-en-1-oxo)butyl is a reactant in the synthesis of Afatinib, an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.
(S)-(+)-3-Hydroxytetrahydrofuran Image

(S)-(+)-3-Hydroxytetrahydrofuran

CAS Number: 86087-23-2
Price: 1
Product Name: (S)-(+)-3-Hydroxytetrahydrofuran (CAS NO.86087-23-2) Molecular Formula: C4H8O2 Molecular Weight: 88.11g/mol Appearance: Colourless Liquid Boiling point: 181 °C at 760 mmHg Flash Point: 81.1 °C Density: 1.148 g/cm3 Refractive index: n20/D 1.45(lit.) Water Solubility: soluble Stability: Stable. Combustible. Incompatible with strong oxidizing agents. Index of Refraction: 1.475 Molar Refractivity: 21.64 cm3 Molar Volume: 76.7 cm3 Surface Tension: 38.7 dyne/cm Enthalpy of Vaporization: 48.57 kJ/mol Vapour Pressure: 0.255 mmHg at 25°C Product Categories: Alcohols, Hydroxy Esters and Derivatives; Chiral Compounds; Starting Raw Materials & Intermediates; Small molecule; Tetrahydrofuran Series; Chiral Reagents; Furans; Chiral Building Blocks; Simple Alcohols (Chiral); Synthetic Organic Chemistry
trans-4-Dimethylaminocrotonic acid hydrochloride Image

trans-4-Dimethylaminocrotonic acid hydrochloride

CAS Number: 848133-35-7
Price: 1
Name:trans-4-dimethylaminocrotonic acid hydrochloride Cas:848133-35-7 Color:white powder Purity:99.0%min Molecular formula:C6H11NO2.HCl Molecular weight:165.62
DIETHYLPHOSPHONOACETIC ACID Image

DIETHYLPHOSPHONOACETIC ACID

CAS Number: 3095-95-2
Price: 1
Diethylphosphonoacetic Acid is a reagent that is used for enantioselective preparation of α-phosphoryl-α,β-unsatd.-δ-aryl-δ-lactones from nonracemic β-hydroxyaldehydes and their conversion to α-methylene-δ-aryl-δ-lactones. Properties: Appearance & Physical State: clear colorless to yellow viscous liquid Density: 1.167g/cm3 Boiling Point: 214.7ºC at 760 mmHg Flash Point: 97.9ºC Refractive Index: 1.414 Storage Condition: Store at 0-5ºC
2,2-Diethoxy-N,N-dimethylethylamine Image

2,2-Diethoxy-N,N-dimethylethylamine

CAS Number: 3616-56-6
Price: 1
Chemical Name: 2,2-Diethoxy-N,N-dimethylethylamine Properties: Appearance & Physical State: Colourless liquid Density: 0.883 Boiling Point: 170ºC Flash Point: 113 °F Refractive Index: 1.411
Idelalisib CAL-101 Image

Idelalisib CAL-101

CAS Number: 870281-82-6
CAL-101 is a highly selective and potent p110δ inhibitor with IC50 of 2.5 nM, is 40- to 300-fold more selective for p110δ relative to other PI3K class I enzymes (p110α, p110β, and p110γ; IC50 are 820, 565, and 89nM, respectively).
idelalisib intermediate Image

idelalisib intermediate

CAS Number: 870281-85-9
CAL-101 is a highly selective and potent p110δ inhibitor with IC50 of 2.5 nM, is 40- to 300-fold more selective for p110δ relative to other PI3K class I enzymes (p110α, p110β, and p110γ; IC50 are 820, 565, and 89nM, respectively).
2-(1-aMinoethyl)-6-Methyl Image

2-(1-aMinoethyl)-6-Methyl

CAS Number: 870281-86-0
Synonyms: 2-(1-aMinoethyl)-6-Methyl; (S)-2-(1-aminoethyl)-6-methylphenol; Phenol,2-(1-aminoethyl)-6-methyl-,(S)-(9CI); (S)-2-(1-amino-propyl)-5-fluoro-3-phenyl-3H-quinazolin-4-one;
Boc-L-2-aminobutyric acid Image

Boc-L-2-aminobutyric acid

CAS Number: 34306-42-8
Appearance & Physical State: White powder Density: 1.101g/cm3 Melting Point: 70-74ºC Boiling Point: 334.5ºC at 760mmHg Flash Point: 156.1ºC Appearance & Physical State: White powder Density: 1.101g/cm3 Melting Point: 70-74ºC Boiling Point: 334.5ºC at 760mmHg Flash Point: 156.1ºC Refractive Index: 1.46 Storage Condition: Store at 0-5ºC
2-Fluoro-6-nitro-N-phenylbenzamide Image

2-Fluoro-6-nitro-N-phenylbenzamide

CAS Number: 870281-83-7
Solubility: Insuluble (5.7E-3 g/L) (25 ºC) Density: 1.411±0.06 g/cm3 (20 ºC 760 Torr) Melting point: 163-165 ºC

2-amino-5-fluoro-N-phenylbenzamide

CAS Number: 60041-89-6
Product Name: 2-AMino-6-flouro-N-phenylbenzaMide Synonyms: 2-AMino-6-flouro-N-phenylbenzaMide;2-amino-5-fluoro-n-phenylbenzamide CAS: 60041-89-6 MF: C13H11FN2O MW: 230.2376432
BIBF1120 Nintedanib Image

BIBF1120 Nintedanib

CAS Number: 928326-83-4
Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.
nintedanib ethanesulfonate salt Image

nintedanib ethanesulfonate salt

CAS Number: 656247-18-6
Synonyms: Nintedanib ethanesulfonate BIBF 1120 esylate BIBF-1120 esylat Nintedanib esylat Nintedanib ethanesulfonate salt BIBF1120/nintedanib ethanesulfonate salt Trinidad Neeb esylate
Nintedanib esylate Image

Nintedanib esylate

CAS Number: 14192-26-8
Synonyms: Methyl 2-oxoindoline-6-carboxylate; Methyl oxindole-6-carboxylate; methyl 2-oxo-1,3-dihydroindole-6-carboxylate Mhyl 2-oxindole-6-carbo... 1-Methoxy-1H-indole-6-carboxylate Methyl 2-oxoindole-6-carboxylate 6-Methoxycarbonyl-2-oxindole methyl 2-oxo-2,3-dihydro-1H-indole-6-carboxylate Methyl2-oxoindoline-6-carboxylate97% 1H-Indole-6-carboxylicacid, 2,3-dihydro-2-oxo-, methyl ester Menthyl 2-oxoindole-6-carboxylate 2-OXO-6-INDOLINECARBOXYLIC ACID METHYL ESTER
Nintedanib Intermediate 2 Image

Nintedanib Intermediate 2

CAS Number: 262368-30-9
Synonyms: N-[(4-methyl-piperazin-1-yl)-methylcarbonyl]-N-methyl-p-phenyldiamine; N-[(4-methyl-piperazin-1-yl)-methylcarbonyl]-N-methyl-p-phenylendiamine; N-(4-Aminophenyl)-N,4-dimethyl-1-piperazineacetamide; N-[(4-methyl-piperazin-1-yl)-methylcarbonyl]-N-methyl-p-phenylenediamine;
N-Methyl-4-nitroaniline Image

N-Methyl-4-nitroaniline

CAS Number: 100-15-2
Appearance & Physical State: Brownish-yellow prisms with violet reflex (from ethanol) or yellow powder Density: 1.2 Melting Point: 149-154ºC Boiling Point: 290.6ºC at 760 mmHg Flash Point: 129.5ºC Refractive Index: 1.619 Stability: Stable. Combustible. Incompatible with strong oxidizing agents. Storage Condition: Keep containers tightly closed. Store in a cool, dry area away from incompatible substances. Vapor Pressure: 0.00205mmHg at 25°C Vapor Density: 5.25 (vs air)
BIBF1120 Intermediate 4 Image

BIBF1120 Intermediate 4

CAS Number: 1168150-46-6
Synonyms: (3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester BIBF1120 Intermediate4 Nintedanib ethanesulfonate intermediates (3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl este methyl (E)-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate 3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester 1H-Indole-6-carboxylic acid, 2,3-dihydro-3-(methoxyphenylmethylene)-2-oxo-, methyl ester, (3E)-
Trimethyl orthobenzoate Image

Trimethyl orthobenzoate

CAS Number: 707-07-3
Appearance & Physical State: clear colorless liquid Density: 1.061 Boiling Point: 87-88ºC (7 mmHg) Flash Point: 82ºC Refractive Index: 1.488-1.49
Tedizolid Phosphate Image

Tedizolid Phosphate

CAS Number: 856867-55-5
Tedizolid phosphate is a novel oxazolidinone with activity against Gram-positive pathogens.
Tedizolid TR-700 Image

Tedizolid TR-700

CAS Number: 856866-72-3
Tedizolid, known as TR-700, is an oral and i.v administered intracellular antibacterial drug.
Tedizolid intermediate 1220910-89-3 Image

Tedizolid intermediate 1220910-89-3

CAS Number: 1220910-89-3
N-[3-Fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl]carbamic Acid Phenylmethyl Ester is an intermediate in the synthesis of Tedizolid, an known oral and intravenous antibiotic.
5-Bromo-2-(2-methyl-2H-tetrazol-5-yl)pyridine Image

5-Bromo-2-(2-methyl-2H-tetrazol-5-yl)pyridine

CAS Number: 380380-64-3
5-Bromo-2-(2-methyl-2H-tetrazol-5-yl)pyridine is a reagent in the synthesis and structure-activity relationship studies of highly potent novel benzoxazinyl-oxazolidinone which is an antibacterial agents. Benzoxazinyl-oxazolidinone had potent activity against Gram-positive pathogens.
Torezolid Intermediate 3 Image

Torezolid Intermediate 3

CAS Number: 444335-16-4
Synonyms: 2-Oxazolidinone,3-(4-bromo-3-fluorophenyl)-5-(hydroxymethyl)-, (5R)- Torezolid Intermediate3 (5R)-3-(4-BROMO-3-FLUOROPHENYL)-5-HYDROXYMETHYLOXAZOLIDIN-2-ONE (5R)-3-(4-broMo-3-fluorophenyl)-5-(hydroxyMethyl)-1,3-oxazolidin-2-one (R)-3-(4-BroMo-3-fluorophenyl)-5-(hydroxyMethyl)oxazolidin-2-one
Tedizolid intermediate H Image

Tedizolid intermediate H

CAS Number: 1056039-83-8
Synonyms: Pyridine, 2-(2-methyl-2H-tetrazol-5-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-;2-(2-Methyl-2H-tetrazol-5-yl)-5-(4;2-(2-Methyl-2H-tetrazol-5-yl)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine;Tedizolid intermediate H;2-(2-Methyl-2H-tetrazol-5-yl)pyridine-5-boronic acid pinacol;Pinacol 2-(2-methyl-2H-tetrazol-5-yl)-5-pyridineboronate;2-(2-Methyl-2H-tetrazol-5-yl)pyridine-5-boronic acid pinacol ester
lesinurad  878672-00-5 Image

lesinurad 878672-00-5

CAS Number: 878672-00-5
Lesinurad is a URAT1 and OAT inhibitor, is determined to be a substrate for the kidney transporters OAT1 and OAT3 with Km values of 0.85 and 2 uM, respectively.
1-Cyclopropyl-4-isothiocyanatonaphthalene Image

1-Cyclopropyl-4-isothiocyanatonaphthalene

CAS Number: 878671-95-5
Synonyms: 1-CYCLOPROPYL-4-ISOTHIOCYANATO-; 1-Cyclopropyl-4-isothiocyanatonaphthalene; 1-cyclopropyl-4-isothiocyanato-naphthalene; 1-cyclopropyl-4-isothiocyanato Naphthalene; NAPHTHALENE, 1-CYCLOPROPYL-4-ISOTHIOCYANATO-;
Lesinurad intermediates 878671-96-6 Image

Lesinurad intermediates 878671-96-6

CAS Number: 878671-96-6
Synonyms: 3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro 3-Amino-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole-5-thiol 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro-3H-1,2,4-Triazole-3-thione 3-Amino-4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione 3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-phthalenyl)-2,4-dihydro 5-amino-4-(4-cyclopropylnaphthalen-1-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione
Lesinurad Impurity 1533519-84-4 Image

Lesinurad Impurity 1533519-84-4

CAS Number: 1533519-84-4
Synonyms: 4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione lesinurad int.4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione 4-(4-Cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole-3-thiol Sodium 2-((4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetate 4-(4-cyclopropylnaphthalen-1-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione Lesinurad Impurity 21 4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione (for Lesinurad) 4-(4-Cyclopropylnaphthalen-1-yl)-1H-1
4-cyclopropylnaphthalen-1-aMine hydrochloride Image

4-cyclopropylnaphthalen-1-aMine hydrochloride

CAS Number: 1533519-92-4
Synonyms: 4-cyclopropylnaphthalen-1-aMine hydrochloride 4-cyclopropylnaphthalen-1-aMine HCl 4-Cyclopropyl-1-naphthalenamine hydrochloride (1:1) 1-Naphthalenamine, 4-cyclopropyl-, hydrochloride 4-cyclopropylnaphthalene –1-amine hydrochloride Lesinurad Impurity 14 HCl 4-Cyclopropyl-1-naphthalenamine HCl 1-Naphthalenamine, 4-cyclopropyl-, hydrochloride (1:1)
lesinurad int Image

lesinurad int

CAS Number: 1533519-85-5
Synonyms: lesinurad int Methyl 2-[[4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]thio]acetate Acetic acid, 2-[[4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-triazol-3-yl]thio]-, methyl ester 2-[[4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-triazol-3-yl]thio]-, methyl ester Lesinurad Impurity 9 Methyl 2-[[4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]thio]acetate(for Lesinurad) 4-triazol-3-yl]thio]acetate Methyl 2-[[4-(4-cyclopropylnaphthalen-1-yl)-4H-1
Formylhydrazine Image

Formylhydrazine

CAS Number: 624-84-0
Hydrazinecarboxaldehyde is used in the synthesis of azaindazoles as inhibitors of bacterial DNA ligase. Also used in the synthesis of anticonvulsants as quinoline derivatives. Properties: Appearance & Physical State: white shiny crystalline flakes Density: 1.325 Boiling Point: 51-58ºC Melting Point: 51-58ºC Flash Point: 112ºC Refractive Index: 1.4576 (20ºC) Water Solubility: Soluble Stability: Stable under normal temperatures and pressures. Moisture sensitive. Storage Condition: 2-8ºC
2-Naphthylamine Image

2-Naphthylamine

CAS Number: 91-59-8
2-Naphthylamine is one of two isomeric aminonaphthalenes, compounds with the formula C10H7NH2. It is a colorless solid, but samples take on a reddish color in air because of oxidiation. The aromatic amine used to be used to make azo dyes. It is a known carcinogen and has largely been replaced by less toxic compounds. Properties: Appearance & Physical State: yellow powder Density: 1.061 Boiling Point: 306ºC Melting Point: 111-113ºC Flash Point: 157.1ºC Refractive Index: 1.6493 (98ºC) Stability: Stable. Incompatible with strong oxidizing agents. Storage Condition: Keep in cool dry location away from ignition sources.
carboxamide Image

carboxamide

CAS Number: 417716-92-8
Lenvatinib is an orally active, multi-target inhibitor, mostly for VEGFR2(KDR)/VEGFR3(Flt-4) with IC50 of 4 nM/5.2 nM, and less potent against VEGFR1/Flt-1, and approximately 10-fold more selective for VEGFR2/3 against FGFR1, PDGFRα/β.
Lenvatinib mesylate Image

Lenvatinib mesylate

CAS Number: 857890-39-2
Lenvatinib, also known as E7080, is a synthetic, orally available inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR/FLK-1) tyrosine kinase with potential antineoplastic activity. E7080 blocks VEGFR2 activation by VEGF, resulting in inhibition of the VEGF receptor signal transduction pathway, decreased vascular endothelial cell migration and proliferation, and vascular endothelial cell apoptosis. Synonyms: lenvatinib Methanesulfonate E7080 Mesylate 4-[3-Chloro-4-[[(cyclopropylamino)carbonyl]amino]phenoxy]-7-methoxy-6-quinolinecarboxamide monomethanesulfonate 4-[3chloro-4-(N'-cyclopropylureido)phenoxy]-7-methoxyquinoline-6-carboxamide methanesulfonate lenvatinib Mesylate
Lenvatinib Intermediates Image

Lenvatinib Intermediates

CAS Number: 417721-36-9
Synonyms: 4-chloro-7-methoxy-quinoline-6-carboxylic acid amide; QC-5355; 6-Quinolinecarboxamide,4-chloro-7-methoxy; 7-methoxy-4-chloro-quinoline-6-carboxamide;
Lenvatinib Intermediate 3 Image

Lenvatinib Intermediate 3

CAS Number: 205448-65-3
Synonyms: Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate 1,4-Dihydro-7-methoxy-4-oxo-6-quinolinecarboxylic acid methyl ester 7-Methoxy-4-oxo-1,4-dihydro-quinoline-6-carboxylic acid methyl ester Lenvatinib Intermediate3 FMX14227-A2 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate methyl 4-hydroxy-7-methoxyquinoline-6-carboxylate 4-dihydroquinoline-6-carboxylate
4-Amino-3-chlorophenol Image

4-Amino-3-chlorophenol

CAS Number: 17609-80-2
Synonyms: EINECS 241-583-3; 2-chloro-4-hydroxyaniline; 4-amino-3-chloro-phenol; 3-chloro-p-aminophenol; 3-Chloro-4-aminophenol;
4-AMINO-3-CHLOROPHENOL HCL Image

4-AMINO-3-CHLOROPHENOL HCL

CAS Number: 52671-64-4
Synonyms: EINECS 241-583-3; 2-chloro-4-hydroxyaniline; 4-amino-3-chloro-phenol; 3-chloro-p-aminophenol; 3-Chloro-4-aminophenol;
Vonoprazan Image

Vonoprazan

CAS Number: 1260141-27-2
Vonoprazan fumarate is a first-in-class potassium-competitive acid blocker. Vonoprazan can be used for the treatment of gastroduodenal ulcer (including some drug-induced peptic ulcers) and reflux esophagitis, and can be combined with antibiotics for the eradication of Helicobacter pylori.
3-Pyridine sulphonyl chloride Image

3-Pyridine sulphonyl chloride

CAS Number: 16133-25-8
Density: 1.489 g/cm3 Melting Point: 144ºC Boiling Point: 284.162ºC at 760 mmHg Flash Point: 125.657ºC Vapor Pressure: 0.000344mmHg at 25°C Safety Statements: S26; S36/37/39 HS Code: 2933399090 RIDADR: UN 3261 Risk Statements: R34 Hazard Codes: Xi
Vonoprazan Impurity Image

Vonoprazan Impurity

CAS Number: 1240948-72-4
Chemical Name: 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile
TAK-438 intermediate 3 Image

TAK-438 intermediate 3

CAS Number: 881674-56-2
Synonyms: 1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)- 5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde 5-(2-Fluorophenyl)-1H-pyrrole-3-carboxaldehyde 1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde TAK-438( Vonoprazan fumarate) intermediate 3 5-(2-Fluorophenyl)pyrrole-3-carboxaldehyde
3-Pyridinesulfonyl chloride HCl Image

3-Pyridinesulfonyl chloride HCl

CAS Number: 42899-76-3
Synonyms: pyridine-3-sulfonyl chloride,hydrochloride; Pyridine-3-sulfonyl chloride hydrochloride; Pyridine-3-Sulfonyl Chloride; Properties: Boiling Point: 314.4ºC at 760 mmHg Melting Point: 120-126ºC Storage Condition: Store below -20ºC
methyl 5-(2-fluorophenyl)-1H-pyrrole-3-carboxylate Image

methyl 5-(2-fluorophenyl)-1H-pyrrole-3-carboxylate

CAS Number: 1240949-59-0
Synonyms: 5-(2-fluorophenyl)-1H-pyrrole-3-carboxylic acid methyl ester; methyl 5-(2-fluorophenyl)-1H-pyrrole-3-carboxylate
4-fluoro-2-methoxy-5-nitrophenylamine Image

4-fluoro-2-methoxy-5-nitrophenylamine

CAS Number: 1075705-01-9
Synonyms: 4-fluoro-2-Methoxy-5-nitroaniline 2-Amino-5-fluoro-4-nitroanisole, 4-Fluoro-5-nitro-o-anisidine 4-Fluoro-2-Methoxy-5-nitrobenzenaMine Benzenamine, 4-fluoro-2-methoxy-5-nitro- 4-fluoro-2-methoxy-5-nitrophenylamine
AZD9291 Image

AZD9291

CAS Number: 1032452-86-0
Synonyms: 3-(2-chloropyriMidin-4-yl)-1-Methylindole 3-(2-chloropyriMidin-4-yl)-1-Methyl-1H-indole 3-(2-Chloro-4-pyrimidinyl)-1-methyl-1H-indole elagolix intermediate 11 EOS-61220
Neratinib Image

Neratinib

CAS Number: 698387-09-6
An oral, irreversible dual EGFR/HER2 inhibitor for breast and non-small cell lung cancer. Antitumor agent. Properties: Density: 1.337 g/cm3 Boiling Point: 756.97ºC at 760 mmHg Flash Point: 411.601ºC
AKOS B033273 Image

AKOS B033273

CAS Number: 524955-09-7
Chemical Name: 3-chloro-4-(pyridin-2-ylmethoxy)aniline Synonyms: 3-chloro-4-(2-pyridinylmethoxy)aniline; 3-CHLORO-4-((PYRIDIN-2-YL)METHOXY)ANILINE; 3-chloro-4-(2-pyridinylMethoxy)-BenzenaMine; 3-chloro-4-(pyridine-2-ylmethoxy)aniline; 4-pyridin-2-yl-methoxy-3-chloroaniline;
hki-272 intermediate Image

hki-272 intermediate

CAS Number: 848133-76-6
Properties: Density: 1.35 g/cm3 Boiling Point: 518.6ºC at 760 mmHg Refractive Index: 1.624
hki-272 Neratinib Image

hki-272 Neratinib

CAS Number: 848139-78-6
4-[4-[(2-Pyridyl)methoxy]-3-chloroanilino]-6-amino-3-cyano-7-ethoxyquinoline, is used in the synthetic preparation of aminopropanamides which is used in irreversible inhibition of epidermal growth factor receptor (EGFR) for potential use in cancer therapy.
Olaparib Image

Olaparib

CAS Number: 763113-22-0
Olaparib (AZD-2281, trade name Lynparza) is an FDA-approved targeted therapy for cancer, developed by KuDOS Pharmaceuticals and later by AstraZeneca. It is a PARP inhibitor, inhibiting poly ADP ribose polymerase (PARP), an enzyme involved in DNA repair. It acts against cancers in people with hereditary BRCA1 or BRCA2 mutations, which include some ovarian, breast, and prostate cancers. In December 2014, olaparib was approved for use as a single agent by the EMA and the FDA. The FDA approval is in for germline BRCA mutated (gBRCAm) advanced ovarian cancer that has received three or more prior lines of chemotherapy.
Cyclopropionic acid Image

Cyclopropionic acid

CAS Number: 1021298-67-8
Synonyms: Carboxycyclopropane; Cyclopropyl Formic Acid; cyclopropane-carboxylic acid; cyclopropanecarboxyllic acid; CYCLOPROPANE CARBOYLIC ACID; Cyclopropanecarboxyl; RARECHEM AL BO 0005; Cyclopropylcarboxylic acid; CPC-ACID;
AZD-2281 Image

AZD-2281

CAS Number: 763114-26-7
Synonyms: 2-fluoro-5-[(4-oxo-3H-phthalazin-1-yl)Methyl]benzoic acid (2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylMethyl)benzoic acid)763114-26-7 Benzoic acid, 5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluoro- 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl) 5-[(3,4-Dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluoro-Benzoic acid 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl) 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid EOS-61877
Palbociclib Image

Palbociclib

CAS Number: 571190-30-2
Palbociclib, also known as PD-0332991, is an orally available cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Palbociclib selectively inhibits cyclin-dependent kinase 4 (CDK4) and 6 (CDK6), thereby inhibiting retinoblastoma (Rb) protein phosphorylation early in the G1 phase leading to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated in many tumor cell types and play a key role in the regulation of cell cycle progression. Properties: Density: 1.313g/cm3 Melting Point: 200 degrees Boiling Point: 711.5 degrees at 760 mmHg Flash Point: 384.1 degrees Refractive Index: 1.647
Palbociclib intermediate Image

Palbociclib intermediate

CAS Number: 571188-59-5
1-Boc-4-(6-aminopyridin-3-yl)piperazine is used to prepare pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of cyclin-dependent kinases 4 and 6. Properties: Density: 1.182g/cm3 Boiling Point: 454.066ºC at 760 mmHg Flash Point: 228.411ºC Refractive Index: 1.569
Palbociclib intermediate Image

Palbociclib intermediate

CAS Number: 1013916-37-4
Chemical Name: 2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7-one Synonyms: QC-4424; 2-chloro-8-cyclopentyl-5-methyl-8H-pyrido[2,3-d]pyrimidin-7-one; 2-Chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one; Pyrido[2,3-d]pyrimidin-7(8H)-one,2-chloro-8-cyclopentyl-5-methyl;
Palbociclib intermediate Image

Palbociclib intermediate

CAS Number: 1016636-76-2
6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido-[2,3-d]pyrimidin-7(8H)-one is used to prepare pyridino[2,3-d]pyrimidin-7(8H)-one derivatives as CDK4 and/or CDK6 inhibitors useful in the treatment of diseases.
CO1686 Rociletinib Image

CO1686 Rociletinib

CAS Number: 1374640-70-6
Rociletinib, also known as AVL-301 and CO1686, is an orally available small molecule, irreversible inhibitor of epidermal growth factor receptor (EGFR) with potential antineoplastic activity. EGFR inhibitor CO-1686 binds to and inhibits mutant forms of EGFR, including T790M, thereby leading to cell death of resistant tumor cells. Compared to other EGFR inhibitors, CO-1686 inhibits T790M, a secondary acquired resistance mutation, as well as other mutant EGFRs and may have therapeutic benefits in tumors with T790M-mediated resistance to other EGFR tyrosine kinase inhibitors.
2-bromo-6-fluoropyridin Image

2-bromo-6-fluoropyridin

CAS Number: 1021426-42-5
Chemical Name: 2-methoxy-4-(4-acetylpiperazinyl)aniline Synonyms: 4-(4-Acetyl-1-piperazinyl)-2-(methyloxy)aniline; 1-(4-(4-aMino-3-Methoxyphenyl)piperazin-1-yl)ethanone; 2-methoxy-4-(4-acetylpiperazinyl)aniline; 2-methoxy-4-(4-acetyl-1-piperazinyl)aniline; 2-methoxy-4-(N-acetyl-piperazin-1-yl)aniline; Rociletinib; 4-(N-acetyl-piperazin-1-yl)-2-methoxyaniline; 2-bromo-6-fluoropyridine;
CO-1686 intermediate Image

CO-1686 intermediate

CAS Number: 1374507-23-9
Chemical Name: N-[3-[[2-Chloro-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]carbamic acid 1,1-dimethylethyl ester Properties: Density: 1.406±0.06 g/cm3 (20 ºC,760mmHg), Calc. Water Solubility: Sparingly Soluble (5.4E-3 g/L) (25 ºC), Calc.
N-Boc-m-phenylenediamine Image

N-Boc-m-phenylenediamine

CAS Number: 68621-88-5
Chemical Name: tert-butyl N-(3-aminophenyl)carbamate; N-Boc-m-phenylenediamine; N-Boc-amino-3-aniline Properties: Density: 1.152g/cm3 Boiling Point: 295.142ºC at 760 mmHg Flash Point: 132.297ºC Refractive Index: 1.583
2-bromo-6-fluoropyridine Image

2-bromo-6-fluoropyridine

CAS Number: 3932-97-6
Chemical Name: 2-methoxy-4-(4-acetylpiperazinyl)aniline Synonyms: 4-(4-Acetyl-1-piperazinyl)-2-(methyloxy)aniline; 1-(4-(4-aMino-3-Methoxyphenyl)piperazin-1-yl)ethanone; 2-methoxy-4-(4-acetylpiperazinyl)aniline; 2-methoxy-4-(4-acetyl-1-piperazinyl)aniline; 2-methoxy-4-(N-acetyl-piperazin-1-yl)aniline; Rociletinib; 4-(N-acetyl-piperazin-1-yl)-2-methoxyaniline; 2-bromo-6-fluoropyridine;
5-Trifluoromethyl-2,4-dichloropyrimidine Image

5-Trifluoromethyl-2,4-dichloropyrimidine

CAS Number: 3932-97-6
2,4-Dichloro-5-trifluoromethylpyrimidine is a reactant in the preparation of pyrimidine derivatives as inhibitors of gene ALK protein Kinase phosphorylating kinase and as cell proliferation inhibitors. Properties: Density: 1.6087 Boiling Point: 230.1ºC at 760 mmHg Refractive Index: 1.4749
Rucaparib intermediate Image

Rucaparib intermediate

CAS Number: 283173-80-8
Synonyms: 2-bromo-8-fluoro-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one 2-Bromo-8-fluoro-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one Rucaparib int 5-bromo-8-fluoro-2,3,4,6-tetrahydro-1H-azepino[5,4,3-cd]indol-1-one 5-bromo-8-fluoro-3,4-dihydro-2H- azepino[5,4,3-cd]indol-1(6H)-one 2-bromo-8-fluoro-4 3-cd]indol-6(3H)-one 5-dihydro-1H-azepino[5
Rucaparib Camsylate Image

Rucaparib Camsylate

CAS Number: 1859053-21-6
Rucaparib is an inhibitor of PARP with a Ki of 1.4 nM for PARP1, and also shows binding affinity to eight other PARP domains. Rucaparib camsylate is a potent, orally available inhibitor of poly ADP-ribose polymerase (PARP) 1 and 2.
Rucaparib phosphate Image

Rucaparib phosphate

CAS Number: 459868-92-9
Rucaparib (AG-014699, PF-01367338) is an inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, also showing binding affinity to eight other PARP domains. Phase 3. Chemical Name:8-fluoro-5-(4-((methylamino)methyl)phenyl)-3,4-dihydro-2H-azepino[5,4,3-cd]indol-1(6H)-one phosphoric acid
Rucaparib PF-01367388 Image

Rucaparib PF-01367388

CAS Number: 283173-50-2
Rucaparib (AG 014699) is a PARP inhibitor being investigated as a potential anti-cancer agent. Rucaparib is the first-in-class clinical candidate targeting the DNA repair enzyme poly-ADPribose polymerase-1 (PARP-1), and was first synthesised as part of a collaboration between scientists working in Northern Institute of Cancer Research and Medical School of Newcastle University, alongside Agouron Pharmaceuticals (San Diego). It is being developed by Clovis Oncology. Rucaparib inhibits "the contraction of isolated vascular smooth muscle, including that from the tumours of cancer patients. It also reduces the migration of some cancer and normal cells in culture."; It can be taken orally in tablet form.
Rucaparib intermediate Image

Rucaparib intermediate

CAS Number: 1408282-26-7
Synonyms: 8-fluoro-1,3,4,5-tetrahydro-azepino[5,4,3-cd]indol-6-one 8-fluoro-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one 8-Fluoro-1,3,4,5-tetrahydro-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one 8-fluoro-3,4-dihydro-2H-azepino[5,4,3-cd]indol-1(6H)-one 8-fluoro-2,3,4,6-tetrahydro-1H-azepino[5,4,3-cd]indol-1-one 6-fluoro-3,10-diazatricyclo[6.4.1.0,13]trideca-1,4(13),5,7-tetraen-9-one
RW3728  6-Fluoro indole-4-Methylcarboxylate Image

RW3728 6-Fluoro indole-4-Methylcarboxylate

CAS Number: 1082040-43-4
Synonyms: RW3728; 6-fluoro-1H-indole-4-carboxylic acid methyl ester; 1H-Indole-4-carboxylic acid, 6-fluoro-, Methyl ester Methyl 6-fluoro-1H-indole-4-carboxylate 6-Fluoro indole-4-Methylcarboxylate methyl 6-Fluoroindole-4-carboxylate
N-(2-Oxoethyl)phthalimide Image

N-(2-Oxoethyl)phthalimide

CAS Number: 2913-97-5
Synonyms: 1,3-dihydro-1,3-dioxo-2H-isoindole-2-acetaldehyde; N-(Formylmethyl)phthalimide; N-Phthalylaminoacetaldehyde; Phthalylglycine aldehyde; (1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)-ACETALDEHYDE; Phthalimidoacetaldehyde; Phthalimideacetaldehyde; 2-(phthalimido)acetaldehyde; N-(2-Oxoethyl)phthalimide; Phthalimide,N-(formylmethyl); 2-(1,3-Dioxoisoindol-2-yl)ethanal; (1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-acetaldehyde; Acetaldehyde,phthalimido; 2-(1,3-Dioxoisoindolin-2-yl)acetaldehyde;
Methyl 5-fluoro-2-methyl-3-nitrobenzoate Image

Methyl 5-fluoro-2-methyl-3-nitrobenzoate

CAS Number: 697739-03-0
Synonyms: 5-FLUORO-2-METHYL-3-NITRO-BENZOIC ACID METHYL ESTER 5-fluoro-2-methyl-3-nitrobenzoic acid Benzoic acid, 5-fluoro-2-Methyl-3-nitro-, Methyl ester 5-fluoro-2-Methyl-3-nitro-, Methyl ester Methyl 5-fluoro-2-Methy-3-nitrobenzoate
ezetimibe intermediate Image

ezetimibe intermediate

CAS Number: 70627-52-0
4-Benzyloxybenzylidene 4-Fluoroaniline is an intermediate in the synthesis of Linezolid. Properties : Appearance & Physical State: light yellow flaky crystal Density: 1.07 Melting Point: 136-138ºC Boiling Point: 455.2ºC at 760 mmHg Refractive Index: 1.558
SCH 58235 Image

SCH 58235

CAS Number: 163222-33-1
Ezetimibe is a drug that lowers plasma cholesterol levels. It acts by decreasing cholesterol absorption in the small intestine. It may be used alone, when other cholesterol-lowering medications are not tolerated, or together with statins (e.g., ezetimibe/simvastatin, marketed as Vytorin and Inegy) when statins alone do not control cholesterol.
Macitentan Intermediates Image

Macitentan Intermediates

CAS Number: 146533-41-7
Synonyms: PyriMidine, 5-(4-broMophenyl)-4,6-dichloro- 5-(4-broMophenyl)-4,6-dichloropyriMidine potassiuM (N-propylsulfaMoyl)aMide 5-(4-Bromophenyl)-4,6-dichloro-1,3-diazine 4,6-Dichloro-5-(4-bromophenyl)pyrimidine (4-broMophenyl)-4,6-dichloroPyriMidine 5-(4-Bromophenyl)-4,6-dichloro-Pyrimidin 5-(4-broMophenyl)-4
n-propylsulfaMide Image

n-propylsulfaMide

CAS Number: 147962-41-2
Synonyms: Sulfamide,propyl; N-propylsulfamide; Propylsulfamide; Properties: Solubility Soluble (53 g/L) (25 ºC), Calc.* Density 1.238±0.06 g/cm3 (20 ºC 760 Torr), Calc.* Boiling point 249.0±23.0 ºC (760 Torr), Calc.* Flash point 104.4±22.6 ºC, Calc.*
N-Propyl-sulfamide potassium salt Image

N-Propyl-sulfamide potassium salt

CAS Number: 1393813-41-6
Synonyms: SulfaMide, N-propyl-,(potassiuM salt)(1:1) N-propylsulfaMoyl AMide PotassiuM SulfaMide, N-propyl-,(potassiuM salt) N-Propyl-sulfaMide potassiuM salt Propylamino-sulfonamide potassium salt N-propyl-,(potassiuM salt)
n-propylsulfamide sodium salt Image

n-propylsulfamide sodium salt

CAS Number: 1642873-03-7
Synonyms: N-Propylsulfuric diamide-sodium n-propylsulfamide sodium salt Propylamino sulfonamide sodium salt
Eltrombopag Intermediate 376592-93-7 Image

Eltrombopag Intermediate 376592-93-7

CAS Number: 376592-93-7
3’-Amino-2’-Hydroxy-[1,1’]Biphenyl-3-carboxylic Acid is used in the synthesis of monoethanolamine salts. A hydrazine cleavage product from Eltrombopag, an agonist of the Thrombopoietin (Tpo) receptor, used as treatment for thrombocytopenia
3-(2-hydroxy-3-nitrophenyl)benzoic acid Image

3-(2-hydroxy-3-nitrophenyl)benzoic acid

CAS Number: 376591-95-6
Chemical Name: 3-(2-hydroxy-3-nitrophenyl)benzoic acid Synonyms: 2-HYDROXY-3A'A inverted exclamation markA'A A'A inverted exclamation markA'A-NITRO-BIPHENYL-3-CARBOXYLIC ACID; [1,1'-Biphenyl]-3-carboxylic acid,2'-hydroxy-3'-nitro; BIP029; 2-HYDROXY-3''-NITRO-BIPHENYL-3-CARBOXYLIC ACID;
4-[4-(Trifluoromethoxy)phenoxy]piperidine Image

4-[4-(Trifluoromethoxy)phenoxy]piperidine

CAS Number: 287952-67-4
4-[4-(Trifluoromethoxy)phenoxy]piperidine is used in the preparation of 3,5-disubstituted isoxazolines as antituberculosis agents. Properties: Density: 1.23g/cm3 Boiling Point: 292.2ºC at 760mmHg Flash Point: 130.5ºC
3-Chloro-4-(3-fluorobenzyloxy)aniline Image

3-Chloro-4-(3-fluorobenzyloxy)aniline

CAS Number: 202197-26-0
3-Chloro-4-(3-fluorobenzyloxy)aniline is an intermediate in the synthesis of Lapatinib. Properties: Density: 1.306 g/cm3 Boiling Point: 387.9ºC at 760 mmHg Flash Point: 188.4ºC Refractive Index: 1.607 Vapor Pressure: 3.19E-06mmHg at 25°C
LDK378 intermediates Image

LDK378 intermediates

CAS Number: 761440-16-8
2,5-Dichloro-N-[2-(isopropylsulfonyl)phenyl]pyrimidin-4-amine is used as a reagent in the synthesis of potent and selective anaplastic lymphoma kinase (ALK-5) inhibitors, used as an anti-tumor treatment.
Ceritinib Image

Ceritinib

CAS Number: 1032900-25-6
Ceritinib is a new ALK gene inhibitor (ALKi) developed by Novartis Pharmaceuticals; its commercial name is Zykadia, and its previous code was LDK378. It was approved by the FDA for sale on April 29, 2014, and it is used to treat anaplastic lymphoma kinase (ALK) positive transfer of crizotinib (CRZ) progress or intolerance of non-small cell lung cancer (NSCLC).
Ceritinib intermediate Image

Ceritinib intermediate

CAS Number: 1380575-45-0
Synonyms: 5-Methyl-2-(1-Methylethoxy)-4- (4-piperidinyl)- BenzenaMine hydrochloride (1:2) 2-isopropoxy-5-Methyl-4-(piperidin-4-yl)aniline dihydrochloride 5-Methyl-2-(1-Methylethoxy)-4- (4-piperidinyl)- BenzenaMine hydrochloride 2-isopropoxy-5-methyl-4-(piperdin-4-yl) aniline dihydrochloride 2-isopropoxy-5-methyl-4-(piperidin-4-yl)aniline hydrochloride LDK378 intermediate 2-ISOPROPOXY-5-METHYL-4-(PIPERIDINE-4- - YL)ANILINE DIHYDROCHLORIDE Benzenamine, 5-methyl-2-(1-methylethoxy)-4-(4-piperidinyl)- (hydrochloride)(1:2)
LDK378 intermediates Image

LDK378 intermediates

CAS Number: 1632485-14-3
Chemical Name: 2,5-Dichloro-N-[2-[(1-methylethyl)thio]phenyl]-4-pyrimidinamine Synonyms: 4-Pyrimidinamine, 2,5-dichloro-N-[2-[(1-methylethyl)thio]phenyl]-;
5-Trifluoromethyl Image

5-Trifluoromethyl

CAS Number: 54-20-6
Properties: Appearance & Physical State: White to faintly yellow crystalline powder Density: 1.554 g/cm3 Melting Point: 242-246ºC Boiling Point: 350ºC Refractive Index: 1.427 Water Solubility: INSOLUBLE Stability: Stable at room temperature in closed containers under normal storage and handling conditions. Storage Condition: -20ºC
6-(Chloromethyl)uracil Image

6-(Chloromethyl)uracil

CAS Number: 18592-13-7
Properties: Density: 1.393g/cm3 Melting Point: 257ºC (dec.) Boiling Point: 493.9ºC at 760 mmHg Flash Point: 252.5ºC Refractive Index: 1.511 Vapor Pressure: 2.23E-10mmHg at 25°C
2-AMinopyrrolidine HCl Image

2-AMinopyrrolidine HCl

CAS Number: 7544-75-4
Synonyms: 2-AMINO-1-PYRROLINE HYDROCHLORIDE 4,5-Dihydro-3H-pyrrol-2-ylamine hydrochloride 2H-Pyrrol-5-amine, 3,4-dihydro-, hydrochloride (1:1) 2-amino-4,5-dihydro-3H-pyrrole HCl salt 2H-Pyrrol-5-amine, 3,4-dihydro-, monohydrochloride 2-Aminopyrrolidine hydrochloride 3,4-Dihydro-2H-pyrrol-5-aMine hydrochloride 2-AMinopyrrolidine HCl Properties: Boiling Point: 211ºC at 760 mmHg Flash Point: 81.4ºC
Rufinamide EP Impurity B Image

Rufinamide EP Impurity B

CAS Number: 217448-86-7
4-Descarboxamido Rufinamide 4-Methyl Ester is an impurity in the synthesis of Rufinamide, an antiepileptic triazole derivative which decreases firing by neurons at sodium channels. Anticonvulsant. Chemical Name: methyl 1-[(2,6-difluorophenyl)methyl]triazole-4-carboxylate