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Taizhou Crene Biotechnology Co., Ltd.

Address:Economic Developed Zone of Taizhou Zhejiang China., Taizhou

Zhejiang, 318000

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afatinib dimaleate Image

afatinib dimaleate

CAS Number: 850140-73-7
Afatinib dimaleate is an irreversible, dual EGFR/HER2 inhibitor, shows potent activity against wild-type and mutant forms of EGFR and HER2, with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2, respectively. Afatinib dimaleate
Cloprostenol Image

Cloprostenol

CAS Number: 40665-92-7
Cloprostenol is a synthetic prostaglandin analogue. Cloprostenol
Latanoprost Lactol Image

Latanoprost Lactol

CAS Number: 352276-28-9
Product name:Latanoprost Lactol Purity:98% min CAS NO:352276-28-9 Solubility:soluble in DMSO Molecular Formula:306.397 Package:Package according to customer requirements Molecular Weight:306.397 Storage: Store at -20℃ Synonyms: LATANOPROST LACTOL (3AR,4R,5R,6AS)-HEXAHYDRO-4-[(3R)-3-HYDROXY-5-PHENYLPENTYL]-2H-CYCLOPENTA[B] FURAN-2,5-DIOL (3AR,4R,5R,6aS)-4-((R)-3-Hydroxy-5-phenylpentyl)-hexahydro-2H-cyclopenta[b]furan-2,5-diol (3aR,4R,5R,6aS)-4-[(3R)-3-hydroxy-5-phenylpentyl]-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]furan-2,5-diol(LatanoprostLactol) 2H-Cyclopenta[b]furan-2,5-diol, hexahydro-4-[(3R)-3-hydroxy-5-phenylpentyl]-, (3aR,4R,5R,6aS)- LT-TRI (3aR,4R,5R,6aS)-4-[(3R)-3-hydroxy-5-phenylpentyl]-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]furan-2,5-diol Latanoprost Lactol
Epoprostenol sodium Image

Epoprostenol sodium

CAS Number: 61849-14-7
Epoprostenol Sodium is a potent vasodilator and antiplatelet substance with a very short physiologic half-life. The sodium salt is used primarily for the treatment of pulmonary hypertension. Epoprostenol sodium inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue.
Epoprostenol Sodium
Bimatoprost amide Image

Bimatoprost amide

CAS Number: 155205-89-3
Synonyms: 9ALPHA,11ALPHA,15S-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROSTA-5Z,13E-DIEN-1-AMIDE;17-PHENYL TRINOR PROSTAGLANDIN F2ALPHA AMIDE;17-phenyl trinor Prostaglandin F2α amide;Bimatoprost amide
Bimatoprost amide
Carboprost Image

Carboprost

CAS Number: 35700-23-3
Carboprost is a synthetic prostaglandin analogue of PGF2α with oxytocic properties. Properties: Appearance & Physical State: White or almost white powder Density: 1.153g/cm3 Boiling Point: 531ºC at 760 mmHg Melting Point: 79-82ºC Flash Point: 289ºC Refractive Index: 1.569
Carboprost
Dinoprost Prostaglandin F2a Image

Dinoprost Prostaglandin F2a

CAS Number: 551-11-1
Prostaglandin F2α (PGF2α in prostanoid nomenclature), pharmaceutically termed dinoprost (INN), is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient. In domestic mammals, it is produced by the uterus when stimulated by oxytocin, in the event that there has been no implantation during the follicular phase. It acts on the corpus luteum to cause luteolysis, forming a corpus albicans and stopping the production of progesterone. Action of PGF2α is dependent on the number of receptors on the corpus luteum membrane. The PGF2α isoform 8-iso-PGF2α was found in significantly increased amounts in patients with endometriosis, thus being a potential causative link in endometriosis-associated oxidative stress.
Dinoprost Prostaglandin F2a
Misoprostol Image

Misoprostol

CAS Number: 59122-46-2
Misoprostol, sold under the brandname Cytotec among others, is a medication used to start labor, cause an abortion, prevent and treat stomach ulcers, and treat postpartum bleeding due to poor contraction of the uterus. For abortions it is often used with mifepristone or methotrexate. By itself effectiveness for this purpose is between 66% and 90%. It is taken either by mouth, under the tongue, or placed in the vagina. Common side effects include diarrhea and abdominal pain. It is pregnancy category X meaning that it is known to result in negative outcomes for the baby if taken during pregnancy. Uterine rupture may occur. It is a prostaglandin analogue — specifically, a synthetic prostaglandin E1 (PGE1).
Misoprostol
Isopropyl unoprostone Image

Isopropyl unoprostone

CAS Number: 120373-24-2
Unoprostone isopropyl is a prostanoid and synthetic docosanoid approved for the treatment of open-angle glaucoma and ocular hypertension.
N-Cyclopropyl Bimatoprost Image

N-Cyclopropyl Bimatoprost

CAS Number: 1138395-12-6
N-Cyclopropyl Bimatoprost
Synonyms:(5Z)-N-Cyclopropyl-7-[(2R)-3,5-dihydroxy-2-(3-hydroxy-5-phenyl-1- penten-1-yl)cyclopentyl]-5-heptenamide
dehydrate limaprost Image

dehydrate limaprost

CAS Number: 853998-94-4
dehydrate limaprost
10,11-Dehydroxy Limaprost is an impurity of Limaprost.
15S-(±)-Cloprostenol Image

15S-(±)-Cloprostenol

CAS Number: 40665-93-8
15S-(±)-Cloprostenol
Properties: Density: 1.321g/cm3 Boiling Point: 628ºC at 760 mmHg Flash Point: 333.6ºC Refractive Index: 1.622
5,6-trans Travoprost Image

5,6-trans Travoprost

CAS Number: 1563176-59-9
5,6-trans Travoprost
Synonyms: 5,6-trans Travoprost;(5E)-7-[(1R,3R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoroMethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-5-heptenoic Acid 1-Methylethyl Ester;(5E)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-5-heptenoic acid 1-methylethyl ester;MKPLKVHSHYCHOC-JPVYXPJZSA-N
15S-Travoprost Image

15S-Travoprost

CAS Number: 340181-93-3
15S-Travoprost
Synonyms: 5-Heptenoic acid, 7-[(1S,2S,3S,5R)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-4-[3-(trifluoroMethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-, 1-Methylethyl ester, (5Z)-;(5Z)-7-[(1S,2S,3S,5R)-3,5-Dihydroxy-2-[(1E,3S)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-butenyl]cyclopentyl]-5-heptenoic acid 1-methylethyl ester;15S-Travoprost;15S-Travopros;isopropyl (Z)-7-((1S,2S,3S,5R)-3,5-dihydroxy-2-((S,E)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)cyclopentyl)hept-5-enoate
(15R)-Bimatoprost Image

(15R)-Bimatoprost

CAS Number: 1163135-92-9
(15R)-Bimatoprost
An intermediate in the production of Bimatoprost.
Bimatoprost Image

Bimatoprost

CAS Number: 155206-00-1
Bimatoprost mildly stimulates the rate of aqueous humor flow during the day (13%) and at night (14%), its ocular hypotensive action is due primarily to a 26% reduction in the tonographic resistance to outflow. Bimatoprost enhances the pressure-sensitive outflow pathway. [1] Bimatoprost displaces [3H]prostaglandin F(2alpha) from FP receptors with K(i) of 6.31 μM. Bimatoprost rapidly mobilizes intracellular Ca(2+) via cloned human FP receptors expressed in human embryonic kidney cells and via native FP receptors in 3T3 mouse fibroblasts with EC(50) of 2.94 μM and 2.2 μM. [2] Bimatoprost up-regulates Cyr61 mRNA expression in the cat iris. Bimatoprost-induced up-regulation of Cyr61 mRNA expression is not because of the activation of the prostaglandin FP receptor but a different receptor. [3] Bimatoprost consistently evokes responses in different cells within the same tissue preparation, whereas prostaglandin F(2 alpha) and 17-phenyl prostaglandin F(2 alpha) elicites signaling responses in the same cells. Bimatoprost selectively stimulates intracellular calcium signaling in different cat iris sphincter cells. [4] Bimatoprost is the ethyl amide derivative of 17-phenyl trinor PGF2α, a potent prostaglandin FP receptor agonist. Bimatoprost elicits an immediate, robust spike in [Ca2+] that rapidly decayes back to baseline levels. Bimatoprost possess direct agonist activities at the rat, mouse, and human FP prostanoid receptor. [5]
Bimatoprost isopropyl ester Image

Bimatoprost isopropyl ester

CAS Number: 130209-76-6
Bimatoprost isopropyl ester is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name Bimatoprost.1 The N-ethyl amide prostaglandin prodrugs are converted to the active free acid more slowly than the analogous prostaglandin ester prodrugs such as latanoprost.2 This product is the isopropyl ester of the free acid prostaglandin which corresponds to Bimatoprost. The free acid, 17-phenyl trinor PGF2α, is a potent FP receptor agonist.3 In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity. The 17-phenyl trinor PGF2α isopropyl ester derivative was examined for IOP-lowering activity during the development of latanoprost.4 At the dose of 3 μg/eye in the monkey, 17-phenyl trinor PGF2α isopropyl ester was the most potent analog tested in reducing IOP, lowering the IOP 1.3 mm Hg below the level achieved by latanoprost. However, this derivative was also significantly more irritating to the eye than latanoprost.4
Latanoprost Image

Latanoprost

CAS Number: 130209-82-4
Latanoprost functioned as both an indirect activator of AMP-activated protein kinase and a selective retinoid X receptor α (RXRα) antagonist able to selectively antagonise the transcription of a RXRα/peroxisome proliferator-activated receptor γ heterodimer[2]. Latanoprost induced morphological abnormality and viability decline of HCS cells in vitro. It induces cell cycle arrest of HCS cells. Latanoprost induces abnormal changes of plasma membrane, DNA fragmentation and ultrastructural abnormality of HCS cells. Caspase activation in HCS cells is also activated by Latanoprost treatment. Latanoprost induces MTP disruption and quantitative changes of mitochondrion-associated pro-apoptotic regulators in HCS cells[1]. Latanoprost is effective in inhibiting adipogenesis, reducing lipogenesis, promoting fatty acid oxidation and enhancing GLUT4 translocation and glucose uptake both in adipocytes and myotubes[2].
Latanoprostene bunod Image

Latanoprostene bunod

CAS Number: 860005-21-6
Latanoprostene bunod is a a nitric oxide (NO)-donating latanoprost with prostaglandin activity. It loweres intraocular pressure (IOP) more effectively than latanoprost in monkeys, dogs and rabbits.
Lubiprostone Image

Lubiprostone

CAS Number: 136790-76-6
Lubiprostone induces a robust secretory response in T84 monolayers. Lubiprostone induces a rise in cAMP levels that was sensitive to EP(4)-receptor blockage in T84 cells. [1] Lubiprostone induces a contraction in rat and human stomach longitudinal muscle, which is inhibited by pretreatment with the EP(1) receptor antagonist but not by the EP(3) or EP(4) receptor antagonists. Lubiprostone also reduces electrically stimulated, neuronal contractions in rat and human colon circular muscle preparations. [2] Lubiprostone (1 mM) stimulates higher elevations in TER despite lower I(sc) responses compared with the nonselective secretory agonist PGE(2) (1 mM). Lubiprostone significantly reduces mucosal-to-serosal fluxes of (3)H-labeled mannitol to levels comparable to those of normal control tissues and restored occludin localization to tight junctions. [3] Lubiprostone causes comparable and maximal increases of I(sc) in T84 cells. Lubiprostone-induced increases in iodide efflux are ~80% of those obtained with forskolin. Lubiprostone activates Cl(-) secretion in T84 cells via cAMP, protein kinase A, and by increasing apical membrane CFTR protein. [4] Lubiprostone, applied to the small intestinal mucosa in eight concentrations ranging from 1-3000 nM, evokes increases in Isc in a concentration-dependent manner with an EC50 of 42.5 nM. Lubiprostone applied to the mucosa of the colon in eight concentrations ranging from 1-3000 nM evokes increases in Isc in a concentration-dependent manner with an EC50 of 31.7 nM. [5]
Tafluprost Image

Tafluprost

CAS Number: 209860-87-7
Tafluprost(AFP-168) is an anti-glaucoma prostaglandin (PG) analog. Target:Others Tafluprost showed significant IOP-lowering effects without any safety concerns in patients with various types of glaucoma and OH in daily clinical practice and tafluprost is highly effective in any therapeutic patterns [1]. Tafluprost with reduced BAK has potential as a superior antiglaucoma drug, not only for its IOP-lowering effect, but also for its good corneal safety profile [2]. Tafluprost single-use vials treatment was effective in reducing IOP over the 3 years of this study, but visual field performance worsened by 10.3%-13.8% in patients with normal-tension glaucoma. Safety was satisfactory [3].
Dinoprostone Image

Dinoprostone

CAS Number: 363-24-6
Dinoprostone has important effects in labour (softening the cervix and causing uterine contraction) and also stimulates osteoblasts to release factors that stimulate bone resorption by osteoclasts.
Dinoprost tromethamine Image

Dinoprost tromethamine

CAS Number: 38562-01-5
Dinoprost tromethamine(Prostaglandin F2α) tromethamine salt is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient.
Prostaglandin E1 (Alprostadil) Image

Prostaglandin E1 (Alprostadil)

CAS Number: 745-65-3
Prostaglandin E1 (Alprostadil)is a prostaglandin, which is used in the treatment of erectile dysfunction and has vasodilatory properties. Target: Prostaglandin Receptor Prostaglandin E1 (PGE1), known pharmaceutically as alprostadil, is a prostaglandin. It is a drug used in the treatment of erectile dysfunction and has vasodilatory properties. In healthy humans, prostaglandin E1 is biosynthesized "on demand" at its intended site of action from dihomo-γ-linolenic acid. Alprostadil is a naturally occurring prostaglandin used in the treatment of infants with congenital heart defects to maintain the patency of the ductus arteriosus until palliative or corrective surgery can be performed. In infants with defects restricting pulmonary blood flow (cyanotic), alprostadil improves arterial blood oxygenation. In infants with defects restricting systemic blood flow, alprostadil improves arterial blood pH, urine output, and femoral arterial pulses. Alprostadil is administered by continuous intraarterial or intravenous infusion, usually at a starting dose of 0.1 microgram/kg/min, with maintenance doses as low as 0.002 microgram/kg/min.
Iloprost Image

Iloprost

CAS Number: 78919-13-8
Iloprost (ZK 36374) is a synthetic analogue of prostacyclin PGI2. Target: Iloprost is a stable prostacyclin analog commonly employed in the treatment of peripheral vascular disease and also indicated in the treatment of patients affected by systemic sclerosis (SSc) in the presence of severe Raynaud's phenomenon (RP).
Limaprost Image

Limaprost

CAS Number: 74397-12-9
Limaprost(OP1206) is a PGE1 analog and potent platelet adhesion inhibitor. Target: Others Limaprost, an alprostadil (prostaglandin E1) analogue, is a vasodilator that increases blood flow and inhibits platelet aggregation. Limaprost is a n analog of PGE1 with structural modifications intended to give a prolonged half-life and greater potency. It is orally active in both guinea pigs and rats at doses of 100 mg/kg as an inhibitor of ADP and collagen induced platelet aggregation. It is 10-1,000 times more potent than PGE1 as a platelet adhesive inhibitor, measured in vitro. Intra-coronary injection (100 ng/kg) or intravenous injection (3 mg/kg) in anesthetized dogs causes vasodilation and increased coronary blood flow by 60-80%. Significant hypotensive effects were seen at 100 and 300 mg/kg orally in rats [1].
Carboprost Tromethamine Image

Carboprost Tromethamine

CAS Number: 58551-69-2
Limaprost(OP1206) is a PGE1 analog and potent platelet adhesion inhibitor. Target: Others Limaprost, an alprostadil (prostaglandin E1) analogue, is a vasodilator that increases blood flow and inhibits platelet aggregation. Limaprost is a n analog of PGE1 with structural modifications intended to give a prolonged half-life and greater potency. It is orally active in both guinea pigs and rats at doses of 100 mg/kg as an inhibitor of ADP and collagen induced platelet aggregation. It is 10-1,000 times more potent than PGE1 as a platelet adhesive inhibitor, measured in vitro. Intra-coronary injection (100 ng/kg) or intravenous injection (3 mg/kg) in anesthetized dogs causes vasodilation and increased coronary blood flow by 60-80%. Significant hypotensive effects were seen at 100 and 300 mg/kg orally in rats [1].
D-Cloprostenol isopropyl ester Image

D-Cloprostenol isopropyl ester

CAS Number: 157283-66-4
D-Cloprostenol isopropyl ester is an isopropyl ester derivative of Cloprostenol (C587300); an aryl-oxymethyl analog of prostaglandin F2α.
(+/-)-Corey lactone diol Image

(+/-)-Corey lactone diol

CAS Number: 54423-47-1
(±)-Corey lactone diol
Synonyms: Lubiprostone Related Compound 6 (3aR,4S,5R,6aS)-hexahydro-5-hydroxy-4-(hydroxymethyl)-2H-cyclopenta[b]furan-2-one; (+/-)-Corey lactone diol; (+/-)-CIS-7-HYDROXY-6-HYDROXYMETHYL-2-OXABICYCLO[3.3.0]OCTAN-3-ONE; 5-Hydroxy-4-(hydroxymethyl)hexahydro-2H-cyclopenta[b]furan-2-one;
(-)-Corey lactone diol Image

(-)-Corey lactone diol

CAS Number: 32233-40-2
(-)-Corey Lactone Diol is an intermediate of Iloprost and shows inhibitory activity towards Beta-lactamase. Iloprost is a synthetic analogue of Prostacyclin (PGI2) used to treat pulmonary arterial hypertension (PAH), scleroderma, Raynaud's phenomenon and ischemia. Properties: Appearance & Physical State: white to beige-brown cryst. powder or crystals Density: 1.365 g/cm3 Melting Point: 117-119 oC(lit.) Boiling Point: 406.6 oC at 760 mmHg Flash Point: 172.9 oC Refractive Index: 1.545 Storage Condition: -20 oC